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Flavor output is more balanced

For the last 3 types of bias, cite which study is less likely to have that particular type of bias (case-control or cohort)

An independent study reported that cultures of stimulated splenic mouse mononuclear cells treated with nicotine showed reduced generation of CTLA-4+ CD4+ T cells and decreased production of INF and IL-2 compared with control cultures without nicotine treatment in vitro (71)

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cigarette smoking on endothelial function by brachial artery duplex ultrasonography: an observational study

HR 1.64 (95% CI 1.411.92) and HR 1.64 (95% CI 1.521.77) respectively (Fig 1 and S2 Table)