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Melanin is a pigment found in the skin responsible for the darkening of skin tone as it consists of blackish-brown eumelanin and reddish-yellowish pheomelanin

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Sometimes these effects end up causing symptoms in those who have heightened histamine sensitivity

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10.1021/jf201166b 125 LingY.GongQ.XiongX.SunL.ZhaoW.ZhuW.et al (2017)