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A multicenter, randomized, open-label, phase 3 trial (LIBRETTO-531) is ongoing to compare selpercatinib to cabozantinib or vandetanib in patients without prior kinase inhibitor therapy in RET -mutant MTC (NCT04211337)

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Subsequent studies also examining data from the FDA Adverse Event Reporting System (FDA AERS) reported an increase in reporting rates of PDAC cases in GLP-1RA users over a broader study period 33,34

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