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Nausea is the most frequently reported side effect, occurring in 20% to 47% of clinical trial participants depending on the dose

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Where Melanotan 1 (afamelanotide) is a linear analogue with high MC1R selectivity, MT-2s cyclic conformation enables it to engage MC1R, MC3R, MC4R, and MC5R making it a multi-pathway melanocortin research tool that has been studied across pigmentation, energy regulation, inflammation, and melanocortin axis pharmacology

But they do basically the same thing