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Stress and Emotional Upset Emotional stress is a well-known trigger for rosacea flare-ups

Starting at lower doses and titrating upward helps minimize side effects and assess tolerability

A 2016 study (Volkova et al., published in Frontiers in Pharmacology) showed it affects the expression of genes involved in GABA signaling, which is the same system benzodiazepines target, but without the sedation or dependency risk

Furthermore, chronic stress aggravates neuronal damage in the amygdala and nucleus accumbens and subsequently disrupts the motivation and reward system (Duman and Voleti, 2012)

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Mike V, Yaguzhinskij LS