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Left untreated, B12 deficiency can cause: Thats why NHS guidelines recommend lifelong supplementation either by injection or oral capsule

This dose-tolerability relationship provides useful guidance for clinical protocol development

Oral AOD 9604 formulations exist but have significantly lower bioavailability than subcutaneous injection

Guidelines for refrigerated lipotropic injections: Store in a refrigerator between 36F and 46F (2C to 8C)

(1995) Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations

If symptoms do not improve despite adequate B12 replacement, further investigation for other causes of nerve pain will be necessary