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In addition, in line with the previously established observations with respect to the role of A2AR signaling in T cell persistence and quiescence state by suppression of TCR-induced activation involving IL-7Rmediated signaling (31, 32), transferred tumor-infiltrating OT-1 T cells decreased CD127 expression upon A2ARi treatment

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The relationship between timing and side effects is not definitively established in clinical trials, as most studies do not systematically compare morning versus evening administration