GLP-1 drugs are best compared with the efficacy of bariatric surgery
Beyond their joint-specific effects, GLP-1RAs have demonstrated systemic anti-inflammatory properties by decreasing levels of C-reactive protein, IL-6, IL-1, and TNF-, and reducing macrophage infiltration into vascular tissues[22]
Ruhoy noted that the GLP-1 receptors are found in many places (brainstem, hippocampus, throughout the gut, mast cells, T and B lymphocytes, natural killer T cells, T-regulatory cells, macrophages, eosinophils, and neutrophils, pancreas, joints, etc.) Both Kaufman and Ruhoy believe the key may lie in the drugs ability to attach to and stabilize mast cells
For instance, in type 2 diabetes, GLP-1RAs improve glycemic control and reduce systemic inflammation
These drugs are metabolized primarily through proteolytic degradation by peptidases throughout the body, not through hepatic cytochrome P450 enzymes or biliary excretion pathways
They also want to preserve muscle, so proteins will have a continued health halo. While traditional weight loss supplements such as fat burners and other pills (sales -10.5% in the year to Oct 6, 2024) will likely suffer, he predicted, other weight management products featuring protein can do quite well as companion products. Meanwhile, so-called active nutrition products featuring protein are also performing well
