Castillo, M
Minimal impact on cortisol or prolactin levels
Key Products: SEP-631, an oral small-molecule negative allosteric modulator (NAM) targeting the MRGPRX2 receptor
August 5, 2023: The European Medicines Agency (EMA) and other agencies are currently investigating whether there is a connection between the use of certain diabetes and weight loss drugs, such as Ozempic, Wegovy, and other glucagon-like peptide-1 (GLP-1) receptor agonists, and an increased risk of suicidal thoughts and self-harm
Understanding your individual genetic predispositionsincluding variants in GLP1R, GIPR, and pain-processing pathwayshelps you and your doctor anticipate side effects and tailor your dose strategy
Large registry-based studies found no increased risk for ileus, intestinal obstruction, pancreatitis, gallbladder disease, or other serious adverse events among patients with IBD receiving GLP-1 RAs