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Activation of innate immunity by 14-3-3 , a new potential alarmin in osteoarthritis

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Patients already on metformin HCl immediate-release (N=431) at a dose of at least 1500 mg per day were randomized after completing a 2-week, single-blind placebo run-in period

14 Increased oxidative stress in the vasculature, however, is not restricted to the endothelium and has also been demonstrated to occur within the smooth muscle cell layer and the adventitia

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