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Food Chem 160:346356 Hwang JH, Chen CC, Lee LY, Chiang HT, Wang MF, Chan YC (2020) Hericium erinaceus enhances neurotrophic factors and prevents cochlear cell apoptosis in senescence accelerated mice

RKIP regulates Raf1 kinase activity, and consequently MAPK signaling, a pathway involved in mediating the antiproliferative effects of SS, and furthermore inhibits G protein receptor kinase 2, possibly affecting SSTRs internalization and degradation ( Beside activation of coupled G proteins, GPCRs are known to directly interact through their intracellular loops with cytoplasmic and surface proteins involved in GPCRs stabilization, desensitization, internalization, and signal transduction